Andrographolide

IAndrographolide yimveliso yebhotani ethathwe kwimifuno eyenzeka ngokwemvelo eTshayina.I-herb inembali ebanzi yokusetyenziswa kwi-TCM kunyango lwezifo eziphezulu zokuphefumula kunye nezinye izifo ezivuthayo kunye nezifo ezithathelwanayo.I-Andrographis paniculata yaziswa kwaye yalinywa eGuangdong nakumazantsi eFujian kwi-50s.Isetyenziselwa ukunyanga izifo ezininzi ezosulelayo kunye nokulunywa yinyoka.Kwiminyaka yakutshanje, ukulima, ukwakheka kweekhemikhali, i-pharmacology kunye nemiba yeklinikhi yeAndrographis paniculata ifundwe eTshayina.I-Andrographis paniculata liyeza eliqhelekileyo laseTshayina elisetyenziswa ngokuqhelekileyo, elineempembelelo zokususa ubushushu kunye netyhefu, igazi elipholileyo kunye ne-detumescence.Eklinikhi, ikakhulu isetyenziselwa unyango losulelo iphecana yokuphefumla, acute bacillary dysentery, gastroenteritis, ingqele, umkhuhlane kunye noxinzelelo lwegazi.Ngokunyuka kokusetyenziswa kakubi kwamayeza okubulala iintsholongwane kunye neempembelelo ezimbi, ilizwi lokuphuhlisa amayeza emveli aseTshayina anesiphumo esihle se-antibacterial liyakhula.I-Andrographis paniculata, njengeyeza lemveli laseTshayina elinempembelelo ye-antibacterial, linikwe ingqalelo ngakumbi nangakumbi lishishini loxubo mayeza.

Isicatshulwa sesityalo se-Andrographis paniculata saziwa ngokuba neentlobo ngeentlobo zemisebenzi yamachiza.I-Andrographolide, eyona nto iphambili yesicatshulwa ibandakanyeka kumsebenzi wayo we-pharmacological.Sifunde iinkqubo zeselula kunye neethagethi ezihlengahlengiswayo ngonyango lwe-andrographolide kumhlaza womntu kunye neeseli zomzimba.Unyango lwe-Andrographolide luthintele ukwanda kwe-in vitro yemigca yeeseli zethumba, emele iintlobo ezahlukeneyo zomhlaza.Ikhompawundi yenza umsebenzi othe ngqo wokulwa nomhlaza kwiiseli zomhlaza ngokubanjwa komjikelo weseli kwisigaba se-G0/G1 ngokungeniswa kweprotheyini ye-cell-cycle inhibitory protein p27 kunye nokuncipha kokubonakaliswa kwe-cyclin-dependent kinase 4 (CDK4).Umsebenzi we-immunostimulatory we-andrographolide ubonakaliswa ngokunyuka kwe-lymphocytes kunye nokuveliswa kwe-interleukin-2.I-Andrographolide ikwaphucule imveliso ye-tumor necrosis factor-alpha kunye ne-CD marker expression, ekhokelela ekwandeni komsebenzi we-cytotoxic we-lymphocytes ngokuchasene neeseli zomhlaza, ezinokuthi zibe negalelo kumsebenzi wayo ongangqalanga wokulwa nomhlaza.Umsebenzi we-in vivo wokulwa nomhlaza wekhompawundi uxhaswa ngakumbi ngokuchasene ne-B16F0 melanoma syngenic kunye nemodeli ye-HT-29 yexenograft.Ezi ziphumo zibonisa ukuba i-andrographolide i-pharmacophore enomdla kunye ne-anticancer kunye nemisebenzi ye-immunomodulatory kwaye ngoko inamandla okuphuhliswa njenge-agent yonyango yomhlaza.