Ii-isoflavones zesoya

Ngo-1931, Kokokuqala ukuba kwakhiwe kwaye kutsalwe kwiimbotyi zesoya.
Ngowe-1962, Sisihlandlo sokuqala ukuqinisekisa ukuba iyafana ne-estrogen eyanyisayo.
Ngo-1986, izazinzulu zaseMelika zafumana i-isoflavones kwiimbotyi zesoya ezinqanda iiseli zomhlaza.
Kwi-1990, i-National Cancer Institute yase-United States yaqinisekisa ukuba i-soy isoflavones zezona zinto zibalaseleyo zendalo.
Phakathi no-1990 ekupheleni, Isetyenziswa kakhulu kumayeza abantu, ukhathalelo lwempilo, ukutya njalo njalo.
Ngo-1996, i-US Food and Drug Administration (FDA) ivuma i-soy isoflavones njengokutya okunempilo.
Ngo-1999, ukutya kwe-Us kunye noLawulo lweDrugs (i-FDA) yavuma ukutya okusebenzayo kwe-soy isoflavones ukungena kwimarike yase-US.
Ukususela kwi-1996, ngaphezu kwe-40 yeemveliso zokutya kwezempilo eziqulethe i-soy isoflavones zivunyiwe e-China.

Sinokubonelela ngeendlela ezahlukeneyo zesoya isoflavones ngokweemfuno zomthengi.
1.I-Soy isoflavones 5%-90%
I-5% ye-isoflavones ye-Soy isetyenziswa ngokubanzi kwintsimi yokutya, i-Flavonoids inemisebenzi ebonakalayo ye-biological kwizilwanyana, ezinokukhuthaza kakhulu ukukhula kwezilwanyana, ukunciphisa ukuchithwa kwamafutha esiswini, ukuphucula ukusebenza kokuzala kunye nokuphucula ukugonywa.
Ummiselo ekukhuleni kwemfuyo yamadoda kunye neenkukhu

Iziphumo zibonise ukuba ukukhula kwezithsaba kwanda ngokukhawuleza, ubunzima bemihla ngemihla bunyuke nge-10%, ubunzima besifuba kunye nemisipha yomlenze bunyuke ngo-6.5% kunye ne-7.26% ngokulandelanayo, kwaye izinga lokusetyenziswa kwesondlo lancitshiswa kakhulu.Umxholo we-DNA ngegram ye-muscle yesifuba yehla nge-8.7% xa kuthelekiswa neqela lokulawula, kodwa akukho tshintsho oluphawulekayo kwi-DNA epheleleyo ye-pectoralis, kunye ne-RNA iyonke yanda nge-16.5%, i-serum urea level iyancipha nge-14.2%, ukusetyenziswa kweprotheyini. izinga linyuke kakhulu, kodwa alibanga nafuthe libalulekileyo kwiibroilers zabasetyhini.Iziphumo zibonise ukuba amanqanaba e-testosterone, i-β - endorphin, i-hormone yokukhula, i-insulin-like growth factor-1, T3, T4 kunye ne-insulin yaphuculwa kakhulu.Iziphumo ezifanayo zafunyanwa kuvavanyo lwamadada e-Gaoyou oyindoda, ubunzima bemihla ngemihla bunyuke nge-16.92%, izinga lokusetyenziswa kwesondlo linyuke nge-7.26%.Inqanaba lilonke lokukhula kwehomoni kwi-serum linyuke nge-37.52% ngokongeza i-500mg / kg isoflavones ye-soy kwisidlo se-boar, kwaye ukuxinwa kwe-urea nitrogen kunye ne-cholesterol ye-metabolites yehla kakhulu.

Impembelelo ekusebenzeni kwemveliso yokubeka iinkukhu
Iziphumo zibonise ukuba inani elifanelekileyo le-daidzein (3-6mg / kg) linokwandisa ixesha lokubeka, ukwandisa izinga lokubeka, ubunzima beqanda kunye nesantya sokuguqulwa kwesondlo.Ukongeza i-6mg / kg i-daidzein ekudleni kweenyanga ezili-12 ezibeka izagwityi zinokunyusa izinga lokubeka nge-10.3% (P0.01).Ukongeza i-3mg / kg i-daidzein ekudleni kwe-Shaoxing ebeka amadada kunokunyusa izinga lokubeka nge-13.13% kunye nesantya sokuguqulwa kwesondlo nge-9.40%.Izifundo zebhayoloji yeemolekyuli zibonakalise ukuba isoflavones yesoya inokukhuthaza kakhulu ukubonakaliswa kofuzo lwe-GH kunye nomxholo we-GH kwiinkukhu, ukukhuthaza ukuzala.

Impembelelo ye-Daidzein kwiimazi ezikhulelweyo
Nangona imveliso yehagu yesintu ibona ukubaluleka kokutyiswa emva kokubeleka, ayinazo iindlela zokulawula ukukhula kwamantshontsho eehagu.Ngokulawulwa kwe-neuroendocrine yomama, ukutshintsha ukukhuselwa kwezondlo, ukukhuthaza ukukhula komntwana kunye nokuphucula umgangatho kunye nobuninzi bokuncancisa likhonkco elibalulekileyo lokuphucula ukusebenza kakuhle kwemveliso yehagu.Iziphumo zibonise ukuba emva kokuba iimazi ezikhulelweyo zondliwa nge-daidzein, inqanaba le-insulin ye-plasma lehla kwaye izinga le-IGF landa.Ukuncancisa kweemazi ngomhla we-10 kunye ne-20 kwakuyi-10.57% kunye ne-14.67% ephezulu kuneqela lolawulo, ngokulandelanayo.Xa kuthelekiswa neqela lokulawula, iziqulatho ze-GH, IGF, TSH kunye ne-PRL kwi-colostrum zanda kakhulu, kodwa umxholo weqanda elimhlophe alikho utshintsho olubalulekileyo.Ukongeza, inqanaba le-antibody yoomama kwi-colostrum liye lanyuka kwaye izinga lokuphila kwamantshontsho eehagu liyenyuka.
I-Soy isoflavones ingenza ngokuthe ngqo kwi-lymphocytes kwaye ikhuthaze isakhono sokuguqula i-lymphocyte eyenziwa yi-PHA ngama-210%.I-isoflavones ye-soy inokwandisa kakhulu umsebenzi wokuzivikela omzimba kunye nokusebenza komzimba kwamalungu e-mammary.I-anti classical swine fever antibody egazini leemazi ezimithiyo kwiqela lovavanyo lonyuke ngama-41%, kwaye loo mthubi wonyuke ngama-44%.

Iziphumo kwizinto ezetyisayo
Iziphumo zabonisa ukuba i-isoflavones yesoya inokuchaphazela ngokuthe ngqo imisebenzi ye-enzymes yokwetyisa ye-rumen microorganisms kunye nokuphucula umsebenzi wabo wokugaya.Kwi-vivo, unyango lwe-soy isoflavones lunyuse kakhulu inqanaba le-testosterone yeenyathi ezingamadoda kunye neegusha, lanyusa iprotein ye-rumen microbial kunye namanqanaba e-asidi eguquguqukayo ewonke, kwaye yaphucula ukukhula kunye nomthamo wemveliso wezilwanyana ezetyisayo.

Impembelelo kwizilwanyana ezincinci
Ngaphambili, ukuzala kwezilwanyana ezincinci ngokuqhelekileyo kwaqala emva kokuzalwa, kodwa kwithiyori, kwakusele kusemva kwexesha.Iimvavanyo zibonise ukuba unyango lweehagu ezikhulelweyo kunye ne-soy isoflavones azigcini nje ukwandisa ukuncancisa, kodwa zandisa izilwa-buhlungu zoomama ebisini.Ukukhula kwamantshontsho eehagu angama- colostrum kunyuke nge-11%, kwaye izinga lokuphila kwamantshontsho aneentsuku ezingama-20 ubudala linyuke nge-7.25% (96.2% vs 89.7%);inzuzo yemihla ngemihla, i-testosterone kunye negazi le-calcium ye-calcium yamantshontsho eehagu ezilunyulweyo eyindoda inyuke ngo-59.15%, 18.41% kunye ne-17.92%, ngokulandelelana, ngelixa imazi yehagu ezilunyulweyo zinyuke nge-5 mg / kg isoflavones yesoya 39%, - 6. 86%, 6 47%.Oku kuvula indlela entsha yokuzala kwamantshontsho ehagu.

I-Aglycon Soy Isoflavones
I-isoflavones yesoya kwiimbotyi zesoya kunye neembotyi zesoya zifumaneka ikakhulu ngohlobo lwe-glycoside, engafuntshwa lula ngumzimba womntu.Xa kuthelekiswa ne-glucoside isoflavones, ii-isoflavones zesoya zasimahla zinomsebenzi ophezulu kuba zinokufunxwa ngqo ngumzimba womntu.Ukuza kuthi ga ngoku, ii-isoflavones ezili-9 kunye neeglucosides ezintathu ezihambelanayo (okt isoflavones yasimahla, ekwaziwa ngokuba ziiglucosides) ziye zabekwa zodwa kwiimbotyi zesoya.

I-Isoflavones luhlobo lwe-metabolites yesibini eyenziwe ekukhuleni kweembotyi zesoya, ngakumbi kwintsholongwane kunye nesidlo seembotyi zesoya sembewu yeembotyi zesoya.I-Isoflavones ziquka i-daidzein, iimbotyi zesoya i-glycoside, i-genistein, i-genistein, i-daidzein, kunye neembotyi zesoya.I-isoflavones yendalo ininzi ikwimo ye-β - glucoside, enokuthi ifakwe i-hydrolyzed ibe yi-isoflavones yamahhala phantsi kwesenzo se-isoflavones eyahlukeneyo ye-glucosidase.I-7, i-Daidzein (i-daidzein, eyaziwa ngokuba yi-daidzein) yenye yezinto eziphambili ze-bioactive kwi-isoflavones yesoya.Kuyaqondwa ukuba inemisebenzi emininzi yefiziyoloji kumzimba womntu.Ukuxutywa kwe-Daidzein emzimbeni womntu ngokuyinhloko kuvela kwiindlela ezimbini: i-liposoluble glycosides inokuthatyathwa ngokuthe ngqo kumathumbu amancinci;i-glycosides ngendlela ye-glycosides ayinakudlula eludongeni lwamathumbu amancinci, kodwa ayinakuxutywa ngodonga lwamathumbu amancinci I-hydrolyzed yi-glucosidase kwikholoni ukuvelisa i-glycoside kwaye ifunnwe ngamathumbu.Iziphumo zovavanyo lwabantu zibonise ukuba i-soy isoflavones yaxutywa kakhulu emathunjini, kwaye izinga lokufunxa laliyi-10-40%.I-Soy isoflavones yaxutywa yi-microvilli, kwaye inxalenye encinci yafihlwa kwi-intestinal cavity nge-bile, kwaye yathatha inxaxheba ekujikelezeni kwesibindi kunye ne-bile.Uninzi lwazo lwathotywa kwaye lwachithwa yi-microorganisms emathunjini nge-heterocyclic lysis, kwaye iimveliso zinokuthi zifakwe egazini.I-isoflavones enemetabolized ikhutshwa ngomchamo.
I-soy isoflavones ifumaneka ikakhulu ngohlobo lweglucosides, ngelixa ukufunxwa kunye nemetabolism ye-soy isoflavones emzimbeni womntu kuqhutywa ngohlobo lwe-soy isoflavones yasimahla.Ke ngoko, ii-isoflavones zasimahla zinegama elithi "isoflavones esebenzayo yesoya".
Isoya isoflavone enyibilikayo ngamanzi 10%